Selected Publications

  1. Collins, J. and Farnsworth, N.L. (2025) Active targeting of type 1 diabetes therapies to pancreatic beta cells using nanocarriers. Diabetologia. https://doi.org/10.1007/s00125-024-06356-5
  2. Collins, J., Bara, J.M., Holcomb, K., Ocampo, A., Fremin, A., Kratz, A., Akolade, J., Hays, J.K., Shileh, A., Hodson, D.J., Broichhagen, J., Russ, H.A., *Farnsworth, N.L. (2024). Peptide-Coated Polycaprolactone-Benzalkonium Chloride Nanocapsules for Targeted Drug Delivery to the Pancreatic β-Cell. ACS Applied Bio Materials Article ASAP. DOI: 10.1021/acsabm.4c0062
  3. Collins, J., Piscopio, R.A., Reyland, M.E., Johansen, C.G., Benninger, R.K.P., *Farnsworth, N.L. (2024). Cleavage of Protein Kinase C δ by Caspase-3 Mediates Pro-inflammatory Cytokine-Induced Apoptosis in the Pancreatic Islet. Journal of Biological Chemistry, 300(9):107611. https://doi.org/10.1101/2022.07.20.500512
  4. Johansen C.G., Holcomb K., Sela A., Morrall S., Park D., Farnsworth N.L. (2024) Extracellular matrix stiffness mediates insulin secretion in pancreatic islets via mechanosensitive Piezo1 channel regulated Ca2+ dynamics. Matrix Biol Plus. 17;22:100148. doi: 10.1016/j.mbplus.2024.100148
  5. Farnsworth, N.L., Piscopio, R., Schleicher, W.E., Ramirez, D.G., Miranda, J.G., Benninger, R.K.P. (2022). Modulation of Gap Junction Coupling within the Islet of Langerhans During the Development of Type 1 Diabetes. Accepted for publication in Frontiers in Physiology.
  6. St. Clair, J.R., Westacott, M.J., Farnsworth, N.L., Kravets, V. Schleicher, W.E., Miranda, J., Heintz, A., Ludin, N.W.F., Benninger, R.K.P. (2020). Restoring Connexin-36 Function in Diabetogenic Environments Precludes Mouse and Human Islet Dysfunction. bioRxiv, doi: https://doi.org/10.1101/2020.11.03.366179.
  7. Farnsworth, N.L.*, Walter, R.*, Piscopio, R., Benninger, R.K.P. (2019). Exendin-4 Overcomes Cytokine-Induced Decreases in Electrical Coupling via PKA and EPAC2 Activation in Mouse and Human Islets. J Physiol, 597(2):431-437.* Indicates co-first authors.
  8. Westacott, M.J.*, Farnsworth, N.*, St. Clair, J., Poffenberger, G., Heintz, A., Powers, A.C., Benninger R.K.P. (2017). Age-dependent decline in the coordinated [Ca2+] and insulin secretory response in human pancreatic islets. Diabetes, 66(9):2436-2445.*Co-first authors.
  9. Farnsworth, N.L., Hemmati, A., Westacott, M.J., Walter, R. L., Benninger, R.K.P. (2015). Low Level Pro-Inflammatory Cytokines Decrease Connexin36 Gap Junction Coupling in Mouse and Human Islets through Nitric Oxide-mediated Protein Kinase Cδ. The Journal of Biological Chemistry, 291:3184-3196.
  10. Farnsworth, N.L., Hemmati, A., Pozzoli, M., Benninger, R.K.P. (2014). Fluorescence recovery after photobleaching reveals regulation and distribution of connexin36 gap junction coupling within mouse islets of Langerhans. Journal of Physiology, 592(Pt 20):4431-4446.